SGCB

sarcoglycan beta

2 disorders 2 untyped 4q12 gene with protein product

HGNC:10806 Monarch NCBI Gene 6443 ENSG00000163069 UniProt Q16585 OMIM 600900

Previous symbols: LGMD2E. Aliases: SGC, A3b.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Autosomal Recessive Limb-Girdle Muscular Dystrophy	untyped	mechanism: Sarcolemmal Instability and Failed Membrane Repair subtype: LGMDR4 scoped to subtype: LGMDR4
Sarcoglycanopathy	untyped	mechanism: Sarcoglycan-Sarcospan Subcomplex Assembly at the Sarcolemma subtype: SGCB scoped to subtype: SGCB

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
autosomal recessive limb-girdle muscular dystrophy MONDO:0015152	AR	Definitive 2024-11-14	Autosomal Recessive Limb-Girdle Muscular Dystrophy untyped

Mechanism modules · computed from kb/

sarcolemmal_fragility_myofiber_necrosis via Autosomal Recessive Limb-Girdle Muscular Dystrophy

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.