Respiratory Syncytial Virus Infection

Infectious Disease MONDO:0001577 Pathograph 2 Show in embeddings browser Viral Respiratory Infection

Respiratory syncytial virus (RSV) infection is an acute respiratory infection caused by human respiratory syncytial virus (human orthopneumovirus; family Pneumoviridae), a negative-sense single-stranded RNA virus. RSV infects the ciliated respiratory epithelium; its fusion (F) glycoprotein mediates entry and cell-cell fusion producing characteristic multinucleated syncytia. RSV is a leading cause of bronchiolitis and pneumonia in infants and one of the leading infectious causes of infant death worldwide, and is an increasingly recognized cause of serious lower respiratory illness and cardiopulmonary decompensation in older and high-risk adults. Severe early-life RSV is mechanistically linked to later wheezing and asthma, and RSV hospitalization in older adults is associated with subsequent cardiovascular events including heart failure.

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1
Pathophys.
7
Phenotypes
2
Pathograph
3
Medical Actions
4
Datasets
C

Comorbidities

Respiratory Syncytial Virus Infection <-> Heart Failure
Disease A A_BEFORE_B CURATED
⚙

Pathophysiology

1
Respiratory Epithelial Infection and Airway Inflammation
RSV infects ciliated airway epithelial cells, and its fusion protein drives cell-cell fusion producing multinucleated syncytia. Epithelial injury, sloughing of necrotic epithelium, mucus hypersecretion, and an inflammatory cellular infiltrate obstruct the small airways (bronchiolitis), causing air trapping and ventilation-perfusion mismatch. The host inflammatory and immune response contributes substantially to disease severity. In older and high-risk adults the same infection can precipitate cardiopulmonary decompensation.
respiratory epithelial cell CL:0002632 Cell Ontology (CL) Relation: this pathophysiological event involves this cell type This pathophysiological event involves respiratory epithelial cell, annotated with epithelial cell of lower respiratory tract (CL:0002632). CL:0002632 is a cell type from the Cell Ontology. ciliated airway epithelial cell CL:0002145 Cell Ontology (CL) Relation: this pathophysiological event involves this cell type This pathophysiological event involves ciliated airway epithelial cell, annotated with multiciliated columnar cell of tracheobronchial tree (CL:0002145). CL:0002145 is a cell type from the Cell Ontology.
viral genome replication GO:0019079 Gene Ontology (GO) Relation: this pathophysiological event involves this biological process This pathophysiological event involves viral genome replication (GO:0019079). GO:0019079 is a biological process from the Gene Ontology. defense response to virus GO:0051607 Gene Ontology (GO) Relation: this pathophysiological event involves this biological process This pathophysiological event involves defense response to virus (GO:0051607). GO:0051607 is a biological process from the Gene Ontology. inflammatory response GO:0006954 Gene Ontology (GO) Relation: this pathophysiological event involves this biological process This pathophysiological event involves increased inflammatory response (GO:0006954). GO:0006954 is a biological process from the Gene Ontology. ↑ INCREASED
bronchiole UBERON:0002186 Uberon multi-species anatomy ontology (UBERON) Relation: this pathophysiological event occurs in this anatomical location This pathophysiological event occurs in bronchiole (UBERON:0002186). UBERON:0002186 is an anatomical location from the Uberon multi-species anatomy ontology. lung UBERON:0002048 Uberon multi-species anatomy ontology (UBERON) Relation: this pathophysiological event occurs in this anatomical location This pathophysiological event occurs in lung (UBERON:0002048). UBERON:0002048 is an anatomical location from the Uberon multi-species anatomy ontology.
Show evidence (3 references)
PMID:27903593 SUPPORT Human Clinical
"Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children in North America and one of the leading causes of death of infants less than 1 year of age worldwide, second only to malaria."
Establishes the major pediatric burden of RSV lower respiratory infection.
PMID:27903593 SUPPORT Human Clinical
"Compounding the burden of acute RSV infections is the exacerbation of preexisting chronic airway diseases and the chronic sequelae of RSV infection."
Supports that RSV exacerbates chronic airway disease and has chronic sequelae beyond the acute infection.
PMID:15858184 SUPPORT Human Clinical
"Respiratory syncytial virus (RSV) is an increasingly recognized cause of illness in adults."
Supports RSV as an important respiratory pathogen in adults, not only children.
⬡

Pathograph

Use the checkboxes to hide or show graph categories. Hover nodes for evidence and cross-linked metadata.
Pathograph: causal mechanism network for Respiratory Syncytial Virus Infection Interactive directed graph showing how pathophysiology mechanisms, phenotypes, genetic factors and variants, experimental models, environmental triggers, and treatments relate through causal and linked edges.
●

Phenotypes

7
Metabolism 1
Fever HP:0001945 Human Phenotype Ontology (HP) Relation: this clinical feature is this phenotype This clinical feature is Fever (HP:0001945). HP:0001945 is a phenotype from the Human Phenotype Ontology.
Respiratory 6
Cough HP:0012735 Human Phenotype Ontology (HP) Relation: this clinical feature is this phenotype This clinical feature is Cough (HP:0012735). HP:0012735 is a phenotype from the Human Phenotype Ontology.
Wheezing HP:0030828 Human Phenotype Ontology (HP) Relation: this clinical feature is this phenotype This clinical feature is Wheezing (HP:0030828). HP:0030828 is a phenotype from the Human Phenotype Ontology.
Dyspnea HP:0002094 Human Phenotype Ontology (HP) Relation: this clinical feature is this phenotype This clinical feature is Dyspnea (HP:0002094). HP:0002094 is a phenotype from the Human Phenotype Ontology.
Tachypnea HP:0002789 Human Phenotype Ontology (HP) Relation: this clinical feature is this phenotype This clinical feature is Tachypnea (HP:0002789). HP:0002789 is a phenotype from the Human Phenotype Ontology.
Hypoxemia HP:0012418 Human Phenotype Ontology (HP) Relation: this clinical feature is this phenotype This clinical feature is Hypoxemia (HP:0012418). HP:0012418 is a phenotype from the Human Phenotype Ontology.
Apnea HP:0002104 Human Phenotype Ontology (HP) Relation: this clinical feature is this phenotype This clinical feature is Apnea (HP:0002104). HP:0002104 is a phenotype from the Human Phenotype Ontology.
💊

Medical Actions

3
Supportive Care
Action: Supportive CareNCI Thesaurus (NCIT) Relation: this treatment is this clinical intervention This treatment is Supportive Care (NCIT:C15747). NCIT:C15747 is a clinical intervention from the NCI Thesaurus. NCIT:C15747
Mainstay of management is supportive (oxygen, hydration, respiratory support); few specific therapeutics exist.
Show evidence (1 reference)
PMID:27903593 SUPPORT Human Clinical
"Despite its global impact on human health, there are relatively few therapeutic options available to prevent or treat RSV infection."
Supports that specific therapeutics are limited and management is largely supportive.
Vaccination
Action: VaccinationNCI Thesaurus (NCIT) Relation: this treatment is this clinical intervention This treatment is Vaccination (NCIT:C15346). NCIT:C15346 is a clinical intervention from the NCI Thesaurus. NCIT:C15346
RSV vaccines (and maternal immunization / monoclonal-antibody prophylaxis) are now used to prevent severe RSV, including in older adults in whom RSV drives serious cardiopulmonary outcomes.
Show evidence (1 reference)
PMID:40696870 SUPPORT Human Clinical
"they underline the importance of vaccination in this population, regardless of pre-existing risk factors."
Supports vaccination of older adults to prevent serious RSV-associated outcomes.
Nirsevimab
Action: PharmacotherapyNCI Thesaurus (NCIT) Relation: this treatment is this clinical intervention This treatment is Pharmacotherapy (NCIT:C15986). NCIT:C15986 is a clinical intervention from the NCI Thesaurus. NCIT:C15986
Agent: nirsevimab NCIT:C170224 NCI Thesaurus (NCIT) Relation: this treatment uses this therapeutic agent This treatment uses nirsevimab (NCIT:C170224). NCIT:C170224 is a therapeutic agent from the NCI Thesaurus.
Nirsevimab is a long-acting recombinant monoclonal antibody against the RSV fusion (F) protein, given as a single injection for passive immunoprophylaxis of infants before the RSV season. By neutralizing the F protein it blocks viral entry/fusion, preventing medically attended RSV lower respiratory tract infection — a broad-spectrum-preventative (passive-immunity) approach.
Mechanism Target:
INHIBITS Respiratory Epithelial Infection and Airway Inflammation — Nirsevimab neutralizes the RSV fusion (F) protein that drives epithelial entry and syncytium formation, preventing productive airway-epithelial infection upstream of bronchiolitis.
Show evidence (1 reference)
PMID:35235726 SUPPORT Human Clinical
"A single injection of nirsevimab administered before the RSV season protected healthy late-preterm and term infants from medically attended RSV-associated lower respiratory tract infection."
MELODY randomized-trial evidence that nirsevimab prophylaxis prevents medically attended RSV lower respiratory tract infection. Evidence source is HUMAN_CLINICAL as this is a randomized controlled trial.
Show evidence (1 reference)
PMID:35235726 SUPPORT Human Clinical
"monoclonal antibody to the RSV fusion protein that has an extended half-life."
Identifies nirsevimab as a long-half-life monoclonal antibody targeting the RSV fusion protein. Evidence source is HUMAN_CLINICAL as this is a randomized controlled trial report.
🦠

Infectious Agent

1
Human respiratory syncytial virus
A negative-sense, single-stranded RNA virus (Pneumoviridae). The attachment (G) and fusion (F) surface glycoproteins mediate binding and membrane fusion; F is the principal target of monoclonal-antibody prophylaxis and current adult/maternal vaccines.
Human respiratory syncytial virus NCBITaxon:11250 NCBI Taxonomy (NCBITaxon)
📊

Related Datasets

4
Porphyromonas gingivalis inhibits Respiratory Syncytial Virus infection while suppressing anti-viral immunity geo:GSE281938
Colonizing microbiota can differentially impact the outcomes of viral infections. While synergistic interactions between invading viruses and specific bacterial colonizers can enhance viral infectivity, resulting in severe disease, other bacteria can play a more antagonistic role by destabilizing viral particles, thus protecting against infection. Here, we explored whether Porphyromonas gingivalis (Pg), a periodontal bacterial pathogen that can translocate to the airways, increases susceptibility to infection with the respiratory syncytial virus (RSV) and Sendai virus (SeV).
human BULK RNA SEQ n=20
PMID:42060722
Identified by GEO DataSets index search for Respiratory Syncytial Virus Infection (scripts/discover_datasets.py); accession and metadata verified against NCBI E-utilities on 2026-08-01. Title, sample count, and organism are GEO's own values.
Nasopharyngeal microbiota, host transcriptome and disease severity in children with respiratory syncytial virus infection geo:GSE77087
Rationale: Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections and hospitalizations in infants worldwide. Known risk factors, however, incompletely explain the variability of RSV disease severity among children. We postulate that severity of RSV infection is influenced in part by modulation of the host immune response by the local microbial ecosystem at the time of infection. Objectives: To define whether different nasopharyngeal microbiota profiles are associated with distinct host transcriptome profiles and severity in children with RSV infection.
human MICROARRAY n=104
PMID:27135599
Identified by GEO DataSets index search for Respiratory Syncytial Virus Infection (scripts/discover_datasets.py); accession and metadata verified against NCBI E-utilities on 2026-08-01. Title, sample count, and organism are GEO's own values.
Human iPS cell-derived respiratory organoids as a model for respiratory syncytial virus infection geo:GSE263272
Respiratory syncytial virus (RSV) is a seasonal respiratory pathogen that primarily affects young children, potentially causing severe lower respiratory tract disease. Despite the high disease burden, understanding of RSV pathophysiology remains limited. To address this, advanced RSV infection models are needed. While HEp-2 cells are widely used due to their high susceptibility to RSV, they do not accurately reflect the host response of the human respiratory tract.
human BULK RNA SEQ n=12
PMID:40262853
Identified by GEO DataSets index search for Respiratory Syncytial Virus Infection (scripts/discover_datasets.py); accession and metadata verified against NCBI E-utilities on 2026-08-01. Title, sample count, and organism are GEO's own values.
TMEM259 alleles modulate respiratory syncytial virus infection and ER-stress-triggered apoptosis ega:EGAS50000001971
Whole Exome Sequencing data for the IRIS1, IRIS2, and IRIS3 cohorts. Abstract: Respiratory syncytial virus (RSV) is a main cause of infant morbidity and mortality. Susceptibility factors for severe RSV bronchiolitis in previously healthy children are unclear. We analyze genetic variants in 5,141 genes involved in virus sensing, interferon (IFN) signaling and effector functions in a population of n=101 previously healthy infants with severe RSV bronchiolitis. Comparing the allele frequencies of the patient cohort with the Exome Aggregation Consortium (ExAC) dataset our analysis reveals 94 non-synonymous coding single nucleotide polymorphisms (SNPs) mapping to 79 potential risk genes.
human WES
European Genome-phenome Archive study, matched because the disease is named in the study's own title ("Respiratory Syncytial Virus Infection"); description-level mentions were not accepted. EGA study_type: Exome Sequencing. Controlled access -- data require a Data Access Agreement. EGA metadata retrieved 2026-08-01.
{ }

Source YAML

click to show 
name: Respiratory Syncytial Virus Infection
creation_date: "2026-06-25T12:00:00Z"
description: >
  Respiratory syncytial virus (RSV) infection is an acute respiratory infection
  caused by human respiratory syncytial virus (human orthopneumovirus; family
  Pneumoviridae), a negative-sense single-stranded RNA virus. RSV infects the
  ciliated respiratory epithelium; its fusion (F) glycoprotein mediates entry and
  cell-cell fusion producing characteristic multinucleated syncytia. RSV is a
  leading cause of bronchiolitis and pneumonia in infants and one of the leading
  infectious causes of infant death worldwide, and is an increasingly recognized
  cause of serious lower respiratory illness and cardiopulmonary decompensation
  in older and high-risk adults. Severe early-life RSV is mechanistically linked
  to later wheezing and asthma, and RSV hospitalization in older adults is
  associated with subsequent cardiovascular events including heart failure.
category: Infectious Disease
parents:
- Viral Respiratory Infection
synonyms:
- RSV infection
- Human respiratory syncytial virus infection
- Human orthopneumovirus infection
disease_term:
  preferred_term: respiratory syncytial virus infection
  term:
    id: MONDO:0001577
    label: respiratory syncytial virus infectious disease
infectious_agent:
- name: Human respiratory syncytial virus
  infectious_agent_term:
    preferred_term: Human respiratory syncytial virus
    term:
      id: NCBITaxon:11250
      label: human respiratory syncytial virus
  description: >
    A negative-sense, single-stranded RNA virus (Pneumoviridae). The attachment
    (G) and fusion (F) surface glycoproteins mediate binding and membrane
    fusion; F is the principal target of monoclonal-antibody prophylaxis and
    current adult/maternal vaccines.
pathophysiology:
- name: Respiratory Epithelial Infection and Airway Inflammation
  description: >
    RSV infects ciliated airway epithelial cells, and its fusion protein drives
    cell-cell fusion producing multinucleated syncytia. Epithelial injury,
    sloughing of necrotic epithelium, mucus hypersecretion, and an inflammatory
    cellular infiltrate obstruct the small airways (bronchiolitis), causing air
    trapping and ventilation-perfusion mismatch. The host inflammatory and
    immune response contributes substantially to disease severity. In older and
    high-risk adults the same infection can precipitate cardiopulmonary
    decompensation.
  cell_types:
  - preferred_term: respiratory epithelial cell
    term:
      id: CL:0002632
      label: epithelial cell of lower respiratory tract
  - preferred_term: ciliated airway epithelial cell
    term:
      id: CL:0002145
      label: multiciliated columnar cell of tracheobronchial tree
  biological_processes:
  - preferred_term: viral genome replication
    term:
      id: GO:0019079
      label: viral genome replication
  - preferred_term: defense response to virus
    term:
      id: GO:0051607
      label: defense response to virus
  - preferred_term: inflammatory response
    term:
      id: GO:0006954
      label: inflammatory response
    modifier: INCREASED
  locations:
  - preferred_term: bronchiole
    term:
      id: UBERON:0002186
      label: bronchiole
  - preferred_term: lung
    term:
      id: UBERON:0002048
      label: lung
  evidence:
  - reference: PMID:27903593
    reference_title: "Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment."
    supports: SUPPORT
    evidence_source: HUMAN_CLINICAL
    snippet: "Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children in North America and one of the leading causes of death of infants less than 1 year of age worldwide, second only to malaria."
    explanation: Establishes the major pediatric burden of RSV lower respiratory infection.
  - reference: PMID:27903593
    reference_title: "Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment."
    supports: SUPPORT
    evidence_source: HUMAN_CLINICAL
    snippet: "Compounding the burden of acute RSV infections is the exacerbation of preexisting chronic airway diseases and the chronic sequelae of RSV infection."
    explanation: Supports that RSV exacerbates chronic airway disease and has chronic sequelae beyond the acute infection.
  - reference: PMID:15858184
    reference_title: "Respiratory syncytial virus infection in elderly and high-risk adults."
    supports: SUPPORT
    evidence_source: HUMAN_CLINICAL
    snippet: "Respiratory syncytial virus (RSV) is an increasingly recognized cause of illness in adults."
    explanation: Supports RSV as an important respiratory pathogen in adults, not only children.
phenotypes:
- category: Respiratory
  name: Cough
  description: Common feature of upper and lower RSV respiratory illness.
  phenotype_term:
    preferred_term: Cough
    term:
      id: HP:0012735
      label: Cough
- category: Respiratory
  name: Wheezing
  description: Small-airway obstruction in RSV bronchiolitis.
  phenotype_term:
    preferred_term: Wheezing
    term:
      id: HP:0030828
      label: Wheezing
- category: Respiratory
  name: Dyspnea
  description: Breathlessness from bronchiolitis/pneumonia.
  phenotype_term:
    preferred_term: Dyspnea
    term:
      id: HP:0002094
      label: Dyspnea
- category: Respiratory
  name: Tachypnea
  description: Rapid breathing, prominent in infant bronchiolitis.
  phenotype_term:
    preferred_term: Tachypnea
    term:
      id: HP:0002789
      label: Tachypnea
- category: Respiratory
  name: Hypoxemia
  description: Low blood oxygen from ventilation-perfusion mismatch.
  phenotype_term:
    preferred_term: Hypoxemia
    term:
      id: HP:0012418
      label: Hypoxemia
- category: Respiratory
  name: Apnea
  description: Can occur in young infants with severe RSV.
  phenotype_term:
    preferred_term: Apnea
    term:
      id: HP:0002104
      label: Apnea
- category: Constitutional
  name: Fever
  description: Common during acute infection.
  phenotype_term:
    preferred_term: Fever
    term:
      id: HP:0001945
      label: Fever
treatments:
- name: Supportive Care
  description: >
    Mainstay of management is supportive (oxygen, hydration, respiratory
    support); few specific therapeutics exist.
  treatment_term:
    preferred_term: Supportive Care
    term:
      id: NCIT:C15747
      label: Supportive Care
  evidence:
  - reference: PMID:27903593
    reference_title: "Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment."
    supports: SUPPORT
    evidence_source: HUMAN_CLINICAL
    snippet: "Despite its global impact on human health, there are relatively few therapeutic options available to prevent or treat RSV infection."
    explanation: Supports that specific therapeutics are limited and management is largely supportive.
- name: Vaccination
  description: >
    RSV vaccines (and maternal immunization / monoclonal-antibody prophylaxis)
    are now used to prevent severe RSV, including in older adults in whom RSV
    drives serious cardiopulmonary outcomes.
  treatment_term:
    preferred_term: Vaccination
    term:
      id: NCIT:C15346
      label: Vaccination
  evidence:
  - reference: PMID:40696870
    reference_title: "Respiratory Syncytial Virus (RSV)-Related Hospitalization and Increased Rate of Cardiovascular Events in Older Adults."
    supports: SUPPORT
    evidence_source: HUMAN_CLINICAL
    snippet: "they underline the importance of vaccination in this population, regardless of pre-existing risk factors."
    explanation: Supports vaccination of older adults to prevent serious RSV-associated outcomes.
- name: Nirsevimab
  description: >-
    Nirsevimab is a long-acting recombinant monoclonal antibody against the RSV
    fusion (F) protein, given as a single injection for passive immunoprophylaxis
    of infants before the RSV season. By neutralizing the F protein it blocks
    viral entry/fusion, preventing medically attended RSV lower respiratory tract
    infection — a broad-spectrum-preventative (passive-immunity) approach.
  therapeutic_modality: MONOCLONAL_ANTIBODY
  treatment_term:
    preferred_term: Pharmacotherapy
    term:
      id: NCIT:C15986
      label: Pharmacotherapy
    therapeutic_agent:
    - preferred_term: nirsevimab
      term:
        id: NCIT:C170224
        label: Nirsevimab
  target_mechanisms:
  - target: Respiratory Epithelial Infection and Airway Inflammation
    treatment_effect: INHIBITS
    description: >-
      Nirsevimab neutralizes the RSV fusion (F) protein that drives epithelial
      entry and syncytium formation, preventing productive airway-epithelial
      infection upstream of bronchiolitis.
    evidence:
    - reference: PMID:35235726
      reference_title: "Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants."
      supports: SUPPORT
      evidence_source: HUMAN_CLINICAL
      snippet: >-
        A single injection of nirsevimab administered before the RSV season
        protected healthy late-preterm and term infants from medically attended
        RSV-associated lower respiratory tract infection.
      explanation: >-
        MELODY randomized-trial evidence that nirsevimab prophylaxis prevents
        medically attended RSV lower respiratory tract infection. Evidence source
        is HUMAN_CLINICAL as this is a randomized controlled trial.
  evidence:
  - reference: PMID:35235726
    reference_title: "Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants."
    supports: SUPPORT
    evidence_source: HUMAN_CLINICAL
    snippet: >-
      monoclonal antibody to the RSV fusion protein that has an extended half-life.
    explanation: >-
      Identifies nirsevimab as a long-half-life monoclonal antibody targeting the
      RSV fusion protein. Evidence source is HUMAN_CLINICAL as this is a randomized
      controlled trial report.
notes: >
  Created as an endpoint entry to support directional comorbidity/trajectory
  modeling of RSV infection as an antecedent of cardiovascular events
  (heart failure) in older adults and of early-life wheezing/asthma.
datasets:
- accession: geo:GSE281938
  title: Porphyromonas gingivalis inhibits Respiratory Syncytial Virus infection while suppressing anti-viral immunity
  description: Colonizing microbiota can differentially impact the outcomes of viral infections. While synergistic interactions between invading viruses and specific bacterial colonizers can enhance viral infectivity, resulting in severe disease, other bacteria can play a more antagonistic role by destabilizing viral particles, thus protecting against infection. Here, we explored whether Porphyromonas gingivalis (Pg), a periodontal bacterial pathogen that can translocate to the airways, increases susceptibility to infection with the respiratory syncytial virus (RSV) and Sendai virus (SeV).
  organism:
    preferred_term: human
    term:
      id: NCBITaxon:9606
      label: Homo sapiens
  data_type: BULK_RNA_SEQ
  sample_count: 20
  publication: PMID:42060722
  notes: Identified by GEO DataSets index search for Respiratory Syncytial Virus Infection (scripts/discover_datasets.py); accession and metadata verified against NCBI E-utilities on 2026-08-01. Title, sample count, and organism are GEO's own values.
- accession: geo:GSE77087
  title: Nasopharyngeal microbiota, host transcriptome and disease severity in children with respiratory syncytial virus infection
  description: 'Rationale: Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections and hospitalizations in infants worldwide. Known risk factors, however, incompletely explain the variability of RSV disease severity among children. We postulate that severity of RSV infection is influenced in part by modulation of the host immune response by the local microbial ecosystem at the time of infection. Objectives: To define whether different nasopharyngeal microbiota profiles are associated with distinct host transcriptome profiles and severity in children with RSV infection.'
  organism:
    preferred_term: human
    term:
      id: NCBITaxon:9606
      label: Homo sapiens
  data_type: MICROARRAY
  sample_count: 104
  publication: PMID:27135599
  notes: Identified by GEO DataSets index search for Respiratory Syncytial Virus Infection (scripts/discover_datasets.py); accession and metadata verified against NCBI E-utilities on 2026-08-01. Title, sample count, and organism are GEO's own values.
- accession: geo:GSE263272
  title: Human iPS cell-derived respiratory organoids as a model for respiratory syncytial virus infection
  description: Respiratory syncytial virus (RSV) is a seasonal respiratory pathogen that primarily affects young children, potentially causing severe lower respiratory tract disease. Despite the high disease burden, understanding of RSV pathophysiology remains limited. To address this, advanced RSV infection models are needed. While HEp-2 cells are widely used due to their high susceptibility to RSV, they do not accurately reflect the host response of the human respiratory tract.
  organism:
    preferred_term: human
    term:
      id: NCBITaxon:9606
      label: Homo sapiens
  data_type: BULK_RNA_SEQ
  sample_count: 12
  publication: PMID:40262853
  notes: Identified by GEO DataSets index search for Respiratory Syncytial Virus Infection (scripts/discover_datasets.py); accession and metadata verified against NCBI E-utilities on 2026-08-01. Title, sample count, and organism are GEO's own values.
- accession: ega:EGAS50000001971
  title: TMEM259 alleles modulate respiratory syncytial virus infection and ER-stress-triggered apoptosis
  description: 'Whole Exome Sequencing data for the IRIS1, IRIS2, and IRIS3 cohorts. Abstract: Respiratory syncytial virus (RSV) is a main cause of infant morbidity and mortality. Susceptibility factors for severe RSV bronchiolitis in previously healthy children are unclear. We analyze genetic variants in 5,141 genes involved in virus sensing, interferon (IFN) signaling and effector functions in a population of n=101 previously healthy infants with severe RSV bronchiolitis. Comparing the allele frequencies of the patient cohort with the Exome Aggregation Consortium (ExAC) dataset our analysis reveals 94 non-synonymous coding single nucleotide polymorphisms (SNPs) mapping to 79 potential risk genes.'
  organism:
    preferred_term: human
    term:
      id: NCBITaxon:9606
      label: Homo sapiens
  data_type: WES
  notes: 'European Genome-phenome Archive study, matched because the disease is named in the study''s own title ("Respiratory Syncytial Virus Infection"); description-level mentions were not accepted. EGA study_type: Exome Sequencing. Controlled access -- data require a Data Access Agreement. EGA metadata retrieved 2026-08-01.'