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Asta Literature Retrieval: Seborrheic dermatitis pathophysiology mechanisms phenotypes diagnosis treatment

2026-03-26
Asta MONDO:0006608 Model: Asta Scientific Corpus Retrieval 20 citations

Asta Literature Retrieval: Seborrheic dermatitis pathophysiology mechanisms phenotypes diagnosis treatment

This report is retrieval-only and is generated directly from Asta results.

  • Papers retrieved: 20
  • Snippets retrieved: 20

Relevant Papers

[1] Seborrheic Dermatitis Revisited: Pathophysiology, Diagnosis, and Emerging Therapies—A Narrative Review

  • Authors: F. N. Navarro Triviño, Juan Pablo Velasco Amador, Irene Rivera Ruiz
  • Year: 2025
  • Venue: Biomedicines
  • URL: https://www.semanticscholar.org/paper/d12ed36ae782d682e06898ab08286c4a2a3e9842
  • DOI: 10.3390/biomedicines13102458
  • PMID: 41153741
  • PMCID: 12562114
  • Citations: 5
  • Influential citations: 0
  • Summary: An updated overview of the pathophysiological mechanisms of seborrheic dermatitis is provided and new therapeutic approaches are under investigation, including PDE4 inhibitors, topical and oral JAK inhibitors, probiotics, and microbiome-targeted therapies.
  • Evidence snippets:
  • Snippet 1 (score: 0.734) > Seborrheic Dermatitis Revisited: Pathophysiology, Diagnosis, and Emerging Therapies—A Narrative Review
  • Snippet 2 (score: 0.597) > The understanding of the mechanisms involved in SD continues to evolve. The current understanding of seborrheic dermatitis recognizes three major pillars in its pathophysiology: alteration of the skin microbiome, dysfunction of sebaceous gland secretion, and the host immune response (Figure 1). A potential fourth factor is genetic predisposition, although its clinical relevance has not yet been fully established.

[2] A narrative review on cutaneous manifestations in polycystic ovary syndrome: pathophysiology, diagnosis, management, and psychosocial impact

  • Authors: Muhammad Farhan, Ariana Seyfi, Afra Alnuaimi, Maya Alamour, Sarah Alwarafi, Haya Elastal, Muhammad Hashir Nazir, Balakrishnan Kamaraj, Hrithik Dakssesh Putta Nagarajan, Deborah Delianne, S. Ganesan, Tirath Patel
  • Year: 2025
  • Venue: Annals of Medicine and Surgery
  • URL: https://www.semanticscholar.org/paper/08773357a797009e40085ec19ec34c8034ed4433
  • DOI: 10.1097/MS9.0000000000003217
  • PMID: 40337376
  • PMCID: 12055046
  • Citations: 3
  • Influential citations: 0
  • Summary: Cutaneous manifestations in PCOS are a cosmetic concern and an essential diagnostic and therapeutic focus in PCOS, and addressing these features can enhance patient outcomes by mitigating physical symptoms and improving quality of life.

[3] SEBORRHEIC DERMATITIS, SCOPING REVIEW

  • Authors: Ana Belén Valero Martillo, Valeria Marilú González Ortiz, Ronald Bolívar Farías Requelme, Johanna Maribel Astudillo Romero, José Eduardo Cango Chamba, Bryam Esteban Coello García
  • Year: 2025
  • Venue: EPRA international journal of multidisciplinary research
  • URL: https://www.semanticscholar.org/paper/cf14dc29cf2092eb80526af065a9cbb7fc88b5f2
  • DOI: 10.36713/epra20013
  • Citations: 0
  • Influential citations: 0
  • Summary: Sborrheic dermatitis has a significant global prevalence, affecting up to 5% of the population, with a higher incidence in individuals with HIV-AIDS, and its pathogenesis has been identified as involving a combination of factors, including Malassezia spp.
  • Evidence snippets:
  • Snippet 1 (score: 0.504) > Introduction: Seborrheic dermatitis (SD) is a common skin disease, where its signs and symptoms may differ according to skin color, associated medical conditions, environmental factors, and vehicle preference. Seborrheic dermatitis is a common skin condition in infants, adolescents and adults, characterized by scaling, erythema and itching, especially on the scalp, face, chest, back, armpits and groin. Objective: to detail the current information related to seborrheic dermatitis, etiology, epidemiology, pathophysiology, histopathology, clinical presentation, evaluation, differential diagnosis, treatment and prognosis. Methodology: a total of 29 articles were analyzed in this review, including review and original articles, as well as clinical cases, of which 23 bibliographies were used because the other articles were not relevant for this study. The sources of information were PubMed, Google Scholar and Cochrane; the terms used to search for information in Spanish, Portuguese and English were: sebopsoriasis, seborrheic dermatitis, seborrheic eczema, dandruff and pityriasis capitis. Results: The most relevant results indicate that seborrheic dermatitis has a significant global prevalence, affecting up to 5% of the population, with a higher incidence in individuals with HIV-AIDS. Its pathogenesis has been identified as involving a combination of factors, including Malassezia spp. colonization of the skin, alteration of the cutaneous microbiota and a deregulated immune response. The most effective treatments are topical, particularly antifungal agents such as ketoconazole and low potency corticosteroids, although treatment should be tailored to the individual characteristics of each patient. Despite being a chronic disease in many cases, early diagnosis and proper management allow control of symptoms and improve the quality of life of patients. Conclusions: Seborrheic dermatitis is a common skin disease, with significant prevalence in various ages and groups, especially in people with HIV-AIDS. Its pathogenesis involves factors such as colonization by Malassezia spp, alterations in the cutaneous microbiota and immune dysregulation. Although it may be self-limiting in some cases, in others

[4] Current Understanding of Seborrheic Dermatitis: Epidemiology, Burden of Disease, and Pathophysiology

  • Authors: I. Turchin, L. Albrecht, Sameh Hanna, Dimitrios Kyritsis, W. J. Loo, Charles W Lynde, V. Prajapati, Kerri Purdy, Linda Rochette, M. Wiseman, Daniel Wong, Geeta Yadav, Jensen Yeung, M. Gooderham
  • Year: 2025
  • Venue: Journal of Cutaneous Medicine and Surgery
  • URL: https://www.semanticscholar.org/paper/dec2d60f25432a8bab477cf6fcdda1586759c38e
  • DOI: 10.1177/12034754251368840
  • PMID: 40965103
  • Citations: 2
  • Influential citations: 0
  • Summary: An updated overview of seborrheic dermatitis epidemiology, burden of disease, and pathophysiology is provided, highlighting the integral roles of microbiome, inflammation, and skin barrier dysfunction in its pathogenesis.

[5] Current Understanding of Seborrheic Dermatitis: Presentation, Diagnosis, and Special Populations

  • Authors: I. Turchin, L. Albrecht, Sameh Hanna, Dimitrios Kyritsis, W. J. Loo, Charles W Lynde, V. Prajapati, Kerri Purdy, Linda Rochette, M. Wiseman, Daniel Wong, Geeta Yadav, Jensen Yeung, M. Gooderham
  • Year: 2025
  • Venue: Journal of Cutaneous Medicine and Surgery
  • URL: https://www.semanticscholar.org/paper/e6881555d3cd8d798a7b2712f9caa15e450c5581
  • DOI: 10.1177/12034754251368828
  • PMID: 40965095
  • Citations: 2
  • Influential citations: 0
  • Summary: Seborrheic dermatitis is a chronic inflammatory skin condition characterized by erythematous patches and plaques with white-to-yellow greasy scale often localized to the scalp and face. Its presentation varies between children and adults, as well as across different skin tones. Notably, in patients with more richly pigmented skin, postinflammatory pigment alteration can also be a feature of seborrheic dermatitis, highlighting the importance of considering skin colour differences in the diagnosis. Clinical manifestations of seborrheic dermatitis can overlap with several other dermatoses, including atopic dermatitis, psoriasis, and rosacea, thereby necessitating careful evaluation for accurate diagnosis. The pathophysiology of seborrheic dermatitis involves a complex interplay between dermatological, neurological, immunological, and microbiome-related factors. The multifaceted nature of seborrheic dermatitis underscores the need for a comprehensive approach to its diagnosis, considering age, skin colour, cultural practices, and comorbidities. This is the second in a series of 3 reviews, each addressing different aspects of seborrheic dermatitis, including its epidemiology, diagnosis, and treatment considerations.

[6] Current Understanding of Seborrheic Dermatitis: Treatment Options

  • Authors: I. Turchin, L. Albrecht, Sameh Hanna, Dimitrios Kyritsis, W. J. Loo, Charles W Lynde, V. Prajapati, Kerri Purdy, Linda Rochette, M. Wiseman, Daniel Wong, Geeta Yadav, Jensen Yeung, M. Gooderham
  • Year: 2025
  • Venue: Journal of Cutaneous Medicine and Surgery
  • URL: https://www.semanticscholar.org/paper/f07f5e09fc9c3184a2684fbd43369ac4b4b2b519
  • DOI: 10.1177/12034754251368824
  • PMID: 40965088
  • Citations: 3
  • Influential citations: 0
  • Summary: The recent development of new treatments, such as the topical phosphodiesterase-4 inhibitor (roflumilast 0.3% foam), shows promise in providing effective, noncorticosteroid options for seborrheic dermatitis management.

[7] Seborrheic Dermatitis: Unraveling mechanisms, clinical fea-tures, and therapeutic possibilities

  • Authors: Nayra Lurian Nascimento de Souza, Vanessa Prada dos Anjos, Karla Andrade, Pedro Henrique Moura Teixeira, J. Lima, Maria Julia Kapp Bressan, Thayane Ribeiro Durante, Ana Beatriz Franco Arena
  • Year: 2025
  • Venue: International Health Sciences Review
  • URL: https://www.semanticscholar.org/paper/e9e9753f518e33fb85a3ec6c6e05e15df85b8a89
  • DOI: 10.70164/ihsr.v1i5.86
  • Citations: 0
  • Influential citations: 0
  • Summary: Treatment includes topical antifungals, corticosteroids, calcineurin inhibitors, keratolytic agents, and specific medicated shampoos, while maintenance regimens are crucial to reduce relapse frequency.

[8] Seborrheic dermatitis - pathogenesis, epidemiology and effective treatment - literature review

  • Authors: Piotr Sobkiewicz, Maciej Józefiak, Joanna Kania, Krzysztof Kania, Maciej Jędrak, Karolina Niekurzak
  • Year: 2023
  • Venue: Journal of Education, Health and Sport
  • URL: https://www.semanticscholar.org/paper/15ed94b90ddc04d39d07b3a677532b738b4ac738
  • DOI: 10.12775/jehs.2023.38.01.016
  • Citations: 0
  • Influential citations: 0
  • Summary: The Pathogenesis of Seborrheic dermatitis is not fully understood, the exact molecular process needs to be examined and patients should be informed that ongoing maintenance treatment will be required.
  • Evidence snippets:
  • Snippet 1 (score: 0.553) > Seborrheic dermatitis - pathogenesis, epidemiology and effective treatment - literature review
  • Snippet 2 (score: 0.512) > Introduction: Seborrheic dermatitis (SD) is common inflammatory dermatology disease. It’s affect up to 3-8% of the population. SD is characterized by erythema yellowish plaques and different level of itching and scaling. The last two symptoms are important factors that affect the quality of life of patients. This condition is usually a reaction to growth of Malassezia spp and commonly develop in regions of strong sebaceous glands such as the scalp, facial area, chest, back. Other factors include increased activity of sebaceous glands, immunosuppression, and stress. Aim of the study: A review of current stage of knowledge on the pathophysiology, epidemiology of Seborrheic Dermatitis. Recommended management with newest guidelines of this disease. The impact of the Covid-19 pandemic and the use of masks on the incidence of Seborrheic Dermatitis. Material and methods: This review was based on available data searched in the PubMed and Google Scholar by using key words: Seborrheic dermatitis, pathophysiology, epidemiology, diagnosis, treatment, clinical presentation, scalp, infant. Conclusion: The Pathogenesis of Seborrheic dermatitis is not fully understood, the exact molecular process needs to be examined. SD is chronic disease with episode of remission and relapse of symptoms. Patients should be informed that ongoing maintenance treatment will be required. Treatment include topical antifungal (ketoconazole, Ciclopirox olamine, zinc pyrithione) and topical anti-inflammatory drugs like mild or mid-strength corticosteroids or calcineurin inhibitors (off-label use). In severe or resistance cases systematic therapy could be necessary. In this situation antifungal drugs (terbinafine, itraconazole) or low dose of isotretinoin are available options. Also new synergic treatments were introduce like cannabinoids or vitamin D which could make therapy more efficiency.

[9] Heart failure with non-reduced ejection fraction: Epidemiology, pathophysiology, phenotypes, diagnosis and treatment approaches.

  • Authors: Y. Cavusoglu, A. Çelik, H. Altay, S. Nalbantgil, Ö. Özden, A. Temizhan, D. Ural, Serkan Ünlü, M. Yılmaz, M. Zoghi
  • Year: 2022
  • Venue: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
  • URL: https://www.semanticscholar.org/paper/1e998ee320fce1b7f2cb77dabab598eb2082d136
  • DOI: 10.5543/tkda.2022.S1
  • PMID: 35969235
  • Citations: 8
  • Influential citations: 0
  • Summary: A comprehensive review including epidemiology, pathophysiology, clinical presentation and phenotypes of HF-NEF and to guide clinicians for the diagnosis and therapeutic approaches based on the available data in the literature is provided.

[10] Patient and Healthcare Provider Perspectives on the Pathway to Diagnosis of Seborrheic Dermatitis in the United States

  • Authors: R. Chovatiya, M. Polaskey, Lakshi M. Aldredge, Candrice R Heath, Moises Acevedo, David H Chu, Diane Hanna, M. Seal, M. Zirwas
  • Year: 2024
  • Venue: Advances in Therapy
  • URL: https://www.semanticscholar.org/paper/333ac895ab55d5a97b0d1c122e8491749b989389
  • DOI: 10.1007/s12325-024-02986-8
  • PMID: 39347927
  • PMCID: 11550289
  • Citations: 1
  • Influential citations: 0
  • Summary: Insight into patient and HCP perspectives about SD diagnosis and management from December 2021 to January 2022 highlights the complexities in the diagnostic and management pathways of SD and underscores the need for a more nuanced understanding and approach in addressing the condition.

[11] A Review of Post-Inflammatory Pigmentation Changes: Pathophysiology, Diagnosis and Treatment.

[12] Experts' view on the management of scalp seborrheic dermatitis in Italy.

[13] Recent Developments and Advances in Atopic Dermatitis: A Focus on Epidemiology, Pathophysiology, and Treatment in the Pediatric Setting

  • Authors: L. Eichenfield, Stephen Stripling, Selwyn Fung, A. Cha, Andryann O’Brien, L. Schachner
  • Year: 2022
  • Venue: Pediatric Drugs
  • URL: https://www.semanticscholar.org/paper/aff13e2dcb3dccbf496f436dd93f3bf898215377
  • DOI: 10.1007/s40272-022-00499-x
  • PMID: 35698002
  • PMCID: 9191759
  • Citations: 82
  • Influential citations: 5
  • Summary: Recent advances in scientific research regarding the mechanisms involved in the pathogenesis of atopic dermatitis that have resulted in the discovery of novel therapeutic targets and the development of targeted biologic therapies with the potential to revolutionize AD therapy are highlighted.

[14] [Pulmonary hypertension associated with left heart diseases: pathophysiology, diagnosis, treatment].

  • Authors: S. Caravita, M. Gori, A. Garascia, C. Baratto, Nino Camassa, S. Carigi, Luisa De Gennaro, Renata De Maria, I. Enea, P. Gentile, F. Giordana, Giuseppe Leonardi, F. Lo Giudice, Francesco Orso, Antonella Romaniello, L. Roncon, M. Tinti, M. Vatrano, M. Vedovati, Marco Marini, C. Picariello
  • Year: 2024
  • Venue: Giornale italiano di cardiologia
  • URL: https://www.semanticscholar.org/paper/d3ea5d861459182a6221eaf8852a876f0aa26287
  • DOI: 10.1714/4187.41757
  • PMID: 38270364
  • Citations: 0
  • Influential citations: 0
  • Summary: The differential diagnosis of PH associated with left heart disease vs pulmonary arterial hypertension (PAH) is challenging in patients with cardiovascular comorbidities, risk factors for PAH and/or a preserved left ventricular ejection fraction.

[15] Seborrheic dermatitis and dandruff: An overview of pathogenesis, role of Malassezia spp., and natural treatment approaches.

[16] Hemodynamic Definitions, Phenotypes, Pathophysiology, and Evaluation of Pulmonary Hypertension Related to Left Heart Disease

[17] Real-World Use of Tapinarof Cream 1% Once Daily in Patients with Seborrheic Dermatitis: A Case Series.

  • Authors: Naiem Issa, Lidia Pomaville
  • Year: 2025
  • Venue: ˜The œJournal of clinical and aesthetic dermatology
  • URL: https://www.semanticscholar.org/paper/5560d7f0b328c373c3fef614831d497d2e521efd
  • PMID: 39830824
  • Citations: 3
  • Influential citations: 0
  • Summary: Tapinarof cream 1% QD used for the treatment of four adults with mild-to-severe SD, demonstrated a rapid onset of efficacy and noticeable improvements in disease activity, indicating a possible remittive effect as previously described in plaque psoriasis.

[18] Time and headache: Insights into timing processes in primary headache disorders for diagnosis, underlying pathophysiology and treatment implications

  • Authors: A. González-Martínez, J. Ray, F. Haghdoost, U. Ashraf, Tuba Cerrahoğlu Şirin, Mia Catherine Dantes, Helin Gosalia, Heewon Hwang, Jee Min Kim, K. S. Lange, Felicia Jennysdotter Olofsgård, E. Caronna, P. Pozo‐Rosich
  • Year: 2024
  • Venue: Cephalalgia
  • URL: https://www.semanticscholar.org/paper/08e60eec04b7ad4d229922f17661e374fd6f1091
  • DOI: 10.1177/03331024241297652
  • PMID: 39558611
  • Citations: 11
  • Influential citations: 0
  • Summary: A comprehensive analysis of time patterns in primary headache disorders underscores their role in phenotyping, understanding and treating primary headache disorders, offering promising avenues for advancing and tailoring headache management.

[19] [Comprehensive considerations for the diagnosis, treatment, and management of osteogenesis imperfecta].

[20] Diabetic Bone Disease: A Comprehensive Narrative Review of Pathophysiology, Diagnosis, and Evidence-Based Management

  • Authors: João Protásio Netto, Vagner Camargo Pires, Mariana Garcia Martins Castro
  • Year: 2025
  • Venue: Diabetology
  • URL: https://www.semanticscholar.org/paper/e08b072b28f129b49d8f6663cb7960c38d3457bd
  • DOI: 10.3390/diabetology6110140
  • Citations: 0
  • Influential citations: 0
  • Summary: Diabetic bone disease represents a distinct clinical entity requiring enhanced diagnostic strategies beyond traditional densitometry, evidence-based treatment selection considering skeletal and metabolic effects, and specialized management protocols extending beyond conventional osteoporosis care.