Sagittal Sinus Thrombosis manual research notes

Provider attempts

• Falcon attempt 1: just research-disorder falcon Sagittal_Sinus_Thrombosis was started from the worktree with EDISON_API_KEY exported from /home/harry/dismech/edison_tok; it remained silent and produced no report file after an extended wait, so it was terminated.
• Falcon attempt 2: retried with the same command under a 900 second timeout; the wrapper returned as a timeout, but complete Falcon report artifacts later appeared at research/Sagittal_Sinus_Thrombosis-deep-research-falcon.md and research/Sagittal_Sinus_Thrombosis-deep-research-falcon.md.citations.md. The Falcon metadata records a duration of 884.48 seconds.
• Cyberian fallback: just research-disorder cyberian Sagittal_Sinus_Thrombosis was run under a 900 second timeout; it also timed out and produced no report file.

The YAML curation was grounded in fetched PubMed references and exact cache snippets. The Falcon report is retained as the generated deep-research artifact, and this manual file records the subset of sources actually converted into the YAML.

Source-backed findings used for curation

• PMID:25073867 supports the clinical presentation spectrum, diagnostic confirmation by MR/MR venography or venous CT, common risk factors, acute heparin anticoagulation, selected thrombolysis/thrombectomy, decompressive surgery, and post-acute anticoagulation.
• PMID:17183977 supports the two linked pathophysiology patterns: local venous infarction with focal signs and global raised intracranial pressure from an obstructed venous system.
• PMID:29039017 supports seizure complications, focal neurological deficits, bleeding/lobar lesions, and the association of superior sagittal sinus thrombosis with secondary seizures in a CVST cohort.
• PMID:38050259 supports the broader CVT epidemiology pattern, variable presentation from headache to loss of consciousness, diagnostic difficulty, first-line heparin treatment, and generally favorable recovery in many patients.
• PMID:39492709 supports contemporary treatment statements: LMWH or unfractionated heparin as first-line acute treatment, decompressive craniectomy for life-threatening intracranial pressure, and specialist-center use of endovascular therapy in complex cases.
• PMID:25899238 supports mechanical thrombectomy as a possible option for patients who do not respond to anticoagulation, while preserving uncertainty because controlled studies are required.

Ontology decisions

• Disease term: MONDO:0002695, label sagittal sinus thrombosis.
• Location term: UBERON:0001642, label superior sagittal sinus.
• Phenotype terms used after OAK verification include HP:0002315 Headache, HP:0002516 Increased intracranial pressure, HP:0001085 Papilledema, HP:0001250 Seizure, HP:0001269 Hemiparesis, HP:0001342 Cerebral hemorrhage, and HP:0007185 Loss of consciousness.
• Mappings added after OAK verification include ICD10CM:I67.6 Nonpyogenic thrombosis of intracranial venous system and MONDO:0002695 sagittal sinus thrombosis.
• Treatment terms use broad but verified actions: MAXO:0000058 pharmacotherapy with CHEBI:28304 heparin, NCIT:C52003 Thrombectomy, and MAXO:0000004 surgical procedure.

Curation notes

• Category was retained as Complex; the literature supports multifactorial thrombotic risk rather than a single Mendelian mechanism for the disorder page as curated here.
• Evidence snippets in the YAML were copied from fetched reference-cache abstracts and kept as direct substrings.
• Unrelated PMIDs fetched during source discovery were not used in the page and should not be staged.