Powassan Virus Disease

**Concrete, grounded next steps I can take now:**

2026-11-04
Claude Code MONDO:0000276 Model: claude-opus-4-8, claude-opus-5-5 Prompt: disease_pathophysiology_research.md f452f0a9c7e3

I'm not going to regenerate that comprehensive from-memory research narrative — the previous attempt was halted by a safety classifier, and I've been instructed not to reproduce it, reworded or otherwise. I'll respect that.

The good news is that a large, unsourced narrative synthesized from memory is also exactly what this repository's curation discipline tells us not to produce. CLAUDE.md is emphatic on this: every CURIE and every citation must be read from a source in the same step it's written, never recalled. So the better path here — both safer and more useful for a dismech entry — is to build the Powassan virus disease entry from verifiable, tool-fetched sources rather than a prose dump.

Here's how I'd propose to proceed on Powassan Virus Disease (MONDO:0000276), which is an infectious-disease entry (no causal gene — the agent is Powassan virus, a tick-borne Flavivirus):

Concrete, grounded next steps I can take now:

  1. Check existing state — whether a stub or entry already exists:
  2. kb/disorders/ for any Powassan entry, and stubs/ for a claim.
  3. Fetch and cache real references so snippets are exact-quote verifiable:
  4. just fetch-reference PMID:<id> for key clinical/epidemiology reviews.
  5. just fetch-reference ORPHA:<code> if Orphanet covers it.
  6. Validate the organism and transmission structure per the infectious-disease granularity ladder (§3e) — at minimum one NCBITaxon-bound infectious_agent and one transmission route, plus agent_life_cycle with the tick vector and reservoir hosts.
  7. Bind terms by lookup, not memory — HP phenotype terms (encephalitis, meningoencephalitis features), UBERON/CL for CNS involvement, NCIT for supportive-care treatments — each resolved via OAK/cache in the step it's written.

Two things I want to confirm before I start:

  • Do you want me to actually create/curate the entry (claim it, fetch references, build the YAML, validate), or did you only want the research write-up? If it's the entry, I'll follow the /curate workflow.
  • Is there a specific deep-research provider report already in research/ for this disease I should be screening as a lead, rather than generating fresh?

Tell me which, and I'll begin with the real tool calls. If instead you genuinely just need a plain clinical reference summary of Powassan virus disease for non-curation purposes, let me know and I can give a brief, source-grounded overview — but I won't re-emit the full templated mechanism/transmission report that was stopped.

Reference Validation

No PMID or DOI references were found in this report.

Term Validation

Checked with linkml-term-validator 0.4.5, through the ols: adapter.

Table (click to expand)
Outcome Count
Terms checked 1
Resolved 1
Unresolved (possible confabulation) 0
Obsolete 0
Unverifiable 0

Every term resolved, and every label the report gave matched.