Major Depressive Disorder

Disorder

• Name: Major Depressive Disorder
• Category: Complex
• Existing deep-research providers: falcon
• Existing evidence reference count in YAML: 28

Key Pathophysiology Nodes

• Monoamine Deficiency
• HPA Axis Dysregulation
• Neuroplasticity Deficits
• Neuroinflammation
• Mitochondrial Dysfunction
• Deep research literature mapping

Citation Inventory (for evidence mapping)

• DOI:10.1007/s40263-024-01114-y
• DOI:10.1038/s41392-024-01738-y
• DOI:10.1101/2025.05.03.25326369
• DOI:10.3390/cells13050423
• DOI:10.3390/ijms25020963
• DOI:10.3390/ijtm4010010