Chronic Myeloid Leukemia, BCR-ABL1 Positive

Disorder

• Name: Chronic Myeloid Leukemia, BCR-ABL1 Positive
• Category:
• Existing deep-research providers: falcon
• Existing evidence reference count in YAML: 19

Key Pathophysiology Nodes

• BCR-ABL1 Fusion Oncogene Formation
• Constitutive Tyrosine Kinase Activation
• RAS-MAPK Pathway Hyperactivation
• PI3K-AKT Pathway Activation
• JAK-STAT Pathway Activation
• Reactive Oxygen Species Generation
• Uncontrolled Myeloid Proliferation
• Apoptosis Resistance
• Genomic Instability and Disease Progression
• Deep research literature mapping

Citation Inventory (for evidence mapping)

• DOI:10.1007/s11899-023-00688-6
• DOI:10.1007/s12672-024-01444-9
• DOI:10.1038/s41375-025-02664-w
• DOI:10.1038/s41467-023-40222-z
• DOI:10.1111/ejh.70006
• DOI:10.1182/blood.2022016896
• DOI:10.2147/jbm.s382090
• DOI:10.31640/ls-2025-4-29
• DOI:10.3389/fonc.2025.1546813
• DOI:10.3389/fphar.2025.1615770
• DOI:10.3390/hematolrep17020018