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Boutonneuse fever

Boutonneuse fever deep-research fallback

⚠️ Fallback MONDO:0024472

Boutonneuse fever deep-research fallback

Date: 2026-05-09

Provider attempts

  • timeout 240s just research-disorder falcon Boutonneuse_Fever timed out with exit code 124.
  • timeout 240s just research-disorder openai Boutonneuse_Fever timed out with exit code 124.

No provider output artifact was produced. Curation proceeded from locally cached Orphanet structured records and PubMed abstracts/full text fetched with just fetch-reference.

Scope used

  • ORPHA:83313 was used as the disease-specific Boutonneuse fever / Mediterranean spotted fever structured record. It supplies the definition, epidemiology, all-ages onset, exact MONDO mapping, and all 26 HPO phenotype rows used in the YAML.
  • ORPHA:101334 was checked because MONDO cross-references it, but it is the African tick typhus record caused by Rickettsia africae; its phenotypes were not transferred to the R. conorii Boutonneuse fever entry.
  • PMID:34698275 was used for the modern review summary of R. conorii subsp. conorii, brown dog tick vector, endothelial dissemination, diagnostic methods, and doxycycline treatment.
  • PMID:26090319 was used as a 250-patient case series for fever, rash, palm and sole involvement, inoculation eschar, blood-test abnormalities, acute renal injury, treatment use, ICU admission, and mortality.
  • PMID:15109588 and PMID:16881414 were used for clinical diagnosis, serology-supported confirmation, disseminated vasculitis, tick-bite prevention context, and antimicrobial treatment.
  • PMID:7691249, PMID:8675654, and PMID:16926398 were used for the endothelial-injury, cytokine, COX-2/prostaglandin, vasculitis, and vascular permeability mechanism chain.

Local audit summary

  • Schema and term validation passed for kb/disorders/Boutonneuse_Fever.yaml.
  • Local snippet audit found all quoted snippets/findings in cached references.
  • Graph-target audit found all downstream and treatment mechanism targets.
  • ORPHA phenotype coverage audit found 26/26 ORPHA:83313 HPO rows represented.