Synaptic Vesicle Cycle Module

This is a mechanism module, not a specific disease. Disorder entries should reference individual nodes via conforms_to using "synaptic_vesicle_cycle#<Node Name>"; the key conformance target is "synaptic_vesicle_cycle#Impaired Calcium-Triggered SNARE-Mediated Vesicle Fusion", the central integrating step of the release machine. The generic cell type is neuron (CL:0000540); conforming entries substitute the disease-relevant subtype (e.g. cortical glutamatergic neuron, GABAergic interneuron, spinal motor neuron at the neuromuscular junction). This module is deliberately presynaptic and complementary to — not a duplicate of — the postsynaptic excitatory_synapse_scaffold_disruption module (PSD scaffold genes such as SHANK3 and SYNGAP1), the network-level epilepsy_excitation_inhibition_imbalance module (which models hyper-synchronous firing rather than the presynaptic release lesion), and the glutamate_excitotoxicity module (receptor-overactivation cell death). The clinical convergence (which specific DEE syndrome, presynaptic myasthenia, or movement disorder results) is disorder-specific and stays on the conforming disorder entries. Module evidence reuses PMIDs that are curated and cached in the conforming disorder entries and in the foundational synaptic-vesicle-cycle and SNAREopathy literature; it is illustrative of the abstracted pattern rather than an exhaustive citation set. Worked conformers span the cycle's arms: SYN1-related disorder (vesicle clustering / reserve pool), STXBP1 encephalopathy and UNC13A congenital NDD (docking/priming), SYT1-associated neurodevelopmental disorder / Baker-Gordon syndrome (the calcium-sensor arm) with the three core SNARE-subunit disorders SNAP25 and STX1B (t-SNAREs) and VAMP2 (v-SNARE) and the SNARE-regulator/fusion-clamp disorder CPLX1, and DNM1 encephalopathy (the endocytosis/recycling arm). These are collected as the Synaptic_Vesicle_Cycle_Disorders grouping.