Hallmarks of Cancer

The six hallmark capabilities, two emerging hallmarks, and two enabling characteristics described by Hanahan and Weinberg in the 2011 framework, represented by ten DisMech mechanism modules.

Published Framework 10 modules 10 framework terms
Home / Modules / Collections / Hallmarks of Cancer · Source YAML

Modules in this collection

Immune Checkpoint Blockade Moduleimmune_checkpoint_blockade
Evading immune destruction

Represents checkpoint-mediated tumor immune evasion together with the treatment mechanism that reverses it.

4 nodes
29 conforming disorders

Framework evidence

PMID:21376230 · Hallmarks of cancer: the next generation.
The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease.

Defines the published organizing framework whose capabilities and enabling characteristics are represented by this collection.

Scope note

This collection represents the 2011 framework. The additional dimensions proposed in the 2022 update are not included until each has a dedicated, correctly scoped mechanism module. This is a navigation and framework record, not a mechanism module or disease grouping; membership does not imply that the modules form one linear causal chain.