RET - dismech genes

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Anaplastic Thyroid Carcinoma	somatic driver somatic	mechanism: MAPK-Activating Truncal Driver Alteration
Multiple Endocrine Neoplasia Type 2	causative germline	mechanism: RET Oncogene Activation subtype: Familial Medullary Thyroid Carcinoma (FMTC); MEN2A; MEN2B
Primary Cutaneous Amyloidosis	susceptibility	subtype: MEN2A-Associated Cutaneous Lichen Amyloidosis scoped to subtype: MEN2A-Associated Cutaneous Lichen Amyloidosis
Hirschsprung Disease	untyped Germline Mutations
Inflammatory Myofibroblastic Tumor	untyped Causal somatic gene rearrangement (ALK-negative subset)
Medullary Thyroid Carcinoma	untyped Germline and Somatic Activating Mutations
Papillary Thyroid Carcinoma	untyped Somatic Gene Fusions
Parathyroid Hyperplasia	untyped Predisposing	scoped to subtype: Primary MGD
Pheochromocytoma and Paraganglioma	untyped Germline Activating Mutations
Renal Agenesis	untyped Ureteric bud outgrowth signaling / CAKUT	mechanism: GDNF receptor complex failure at the Wolffian duct scoped to subtype: Syndromic
RET Fusion-Positive Thyroid Cancer	untyped Somatic Gene Fusions
RET-Rearranged Non-Small Cell Lung Cancer	untyped Somatic Rearrangement
Medullary Sponge Kidney	no genetic record	mechanism: Disrupted GDNF-RET Signaling at the Ureteric Bud-Metanephric Mesenchyme Interface

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
multiple endocrine neoplasia type 2B MONDO:0008082	AD	Definitive 2020-05-14	Multiple Endocrine Neoplasia Type 2 causative
multiple endocrine neoplasia type 2A MONDO:0008234	AD	Definitive 2020-05-14	Multiple Endocrine Neoplasia Type 2 causative

Mechanism modules · computed from kb/

sustaining_proliferative_signaling via Anaplastic Thyroid Carcinoma

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.