Aliases: TC-25, p21-Rac1, Rac-1.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Intellectual Disability, Autosomal Dominant 48 | causative germline |
mechanism: De Novo RAC1 Missense Variant Altering the GTPase Switch
|
| Adams-Oliver Syndrome | no genetic record |
mechanism: RAC1-SRF Cranial Mesenchyme Defect
animal model: Mouse (Mus musculus)
|
| ARHGDIA-Related Steroid-Resistant Nephrotic Syndrome | no genetic record |
mechanism: Impaired RhoGDIalpha-GTPase Interaction; RAC1 Hyperactivation in Podocytes
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| syndromic intellectual disability MONDO:0000508 | AD | Definitive 2023-09-20 |
no dismech entry |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.