PRNP

prion protein (Kanno blood group)

2 disorders 2 causative 2 modifier 20p13 gene with protein product

HGNC:9449 Monarch NCBI Gene 5621 ENSG00000171867 UniProt F7VJQ1 UniProt P04156 OMIM 176640

Previous symbols: PRIP, GSS, CJD. Aliases: CD230, PRP, AltPrP.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Fatal Familial Insomnia	causativemodifier germline	mechanism: PRNP D178N-129M Germline Allele
Gerstmann-Straussler-Scheinker Syndrome	causativemodifier germline

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.