PARN

poly(A)-specific ribonuclease

3 disorders 3 causative 16p13.12 gene with protein product

HGNC:8609 Monarch NCBI Gene 5073 ENSG00000140694 UniProt O95453 OMIM 604212

Aliases: DAN.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Dyskeratosis Congenita	causative germline	mechanism: Impaired Telomere Maintenance subtype: PARN scoped to subtype: PARN
Dyskeratosis Congenita Autosomal Recessive 6	causative
Idiopathic Pulmonary Fibrosis	causative	mechanism: Alveolar epithelial telomere dysfunction

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
pulmonary fibrosis and/or bone marrow failure, Telomere-related, 4 MONDO:0014612	SD	Definitive 2024-10-25	no dismech entry

Mechanism modules · computed from kb/

telomere_attrition via Idiopathic Pulmonary Fibrosis

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.