Aliases: TRK, TRKA, MTC.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Congenital Insensitivity to Pain | causative germline |
mechanism: Developmental nociceptor apoptosis; Impaired NGF-TRKA-dependent macrophage killing; NGF-TRKA trophic signaling failure
subtype: HSAN IV
scoped to subtype: HSAN IV
|
| Fibrosarcoma | somatic driver somatic | |
| Hereditary Sensory and Autonomic Neuropathy |
untyped
Causal
|
mechanism: Impaired NGF-TrkA Neurotrophic Signaling
scoped to subtype: HSAN4
|
| NTRK Fusion-Positive Cancer |
untyped
Somatic Gene Fusions
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| hereditary sensory and autonomic neuropathy type 4 MONDO:0009746 | AR | Definitive 2021-11-17 |
Congenital Insensitivity to Pain
causative
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.