Previous symbols: ATA, ATDC, ATC, ATD. Aliases: TEL1, TELO1.
ai-gene-review has this gene at status DRAFT; the description is shown only once the review is complete. Read the draft upstream.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Angiosarcoma | unknown somatic | |
| Ataxia-telangiectasia | causative germline |
mechanism: ATM kinase deficiency and defective DNA-damage signaling
subtype: Classic ataxia-telangiectasia; Variant ataxia-telangiectasia
computational model: ATM p.Ala2386Glu variant-structure predictions; ATM/ATR DNA-damage-response and drug-repurposing ODE model
treatment: Atipeksen for ATM c.7865C>T
|
| Mantle Cell Lymphoma |
untyped
Intermediate-Risk Marker
|
|
| Pancreatic Ductal Adenocarcinoma |
untyped
Inherited susceptibility
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| ataxia telangiectasia MONDO:0008840 | AR | Definitive 2021-07-27 |
Ataxia-telangiectasia
causative
|
| ATM-related cancer predisposition MONDO:0700270 | AD | Definitive 2024-11-22 |
no dismech entry |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.