NOG

noggin

4 disorders 2 causative 2 untyped 17q22 gene with protein product

HGNC:7866 Monarch NCBI Gene 9241 ENSG00000183691 UniProt Q13253 OMIM 602991

Previous symbols: SYNS1, SYM1.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Brachydactyly Type B2	causative germline	mechanism: Subtle Alteration of NOGGIN Ligand Binding
NOG-Related Symphalangism Spectrum Disorder	causative germline CLINGEN: definitive	mechanism: NOG Loss of Function
Humeroradial Synostosis	untyped Causative
Multiple Synostoses Syndrome	untyped Causative	mechanism: BMP Signaling Dysregulation

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
NOG-related symphalangism spectrum disorder MONDO:0100521	AD	Definitive 2023-07-05	NOG-Related Symphalangism Spectrum Disorder causative

Mechanism modules · computed from kb/

limb_digit_patterning_serial_homology via Brachydactyly Type B2

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.