NGF - dismech genes

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Congenital Insensitivity to Pain	causative germline	mechanism: Developmental nociceptor apoptosis; Impaired NGF-TRKA-dependent macrophage killing; NGF-TRKA trophic signaling failure subtype: HSAN V scoped to subtype: HSAN V
Hereditary Sensory and Autonomic Neuropathy	untyped Causal	mechanism: Impaired NGF-TrkA Neurotrophic Signaling scoped to subtype: HSAN5

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
hereditary sensory and autonomic neuropathy MONDO:0015364	AR	Strong 2023-05-05	Hereditary Sensory and Autonomic Neuropathy untyped

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.