Previous symbols: NFKBI. Aliases: IKBA, MAD-3, IkappaBalpha.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Classic Hodgkin Lymphoma | somatic driver somatic |
mechanism: Mutation-Driven NF-kappaB Activation
|
| Ectodermal Dysplasia and Immunodeficiency 2 |
untyped
CAUSATIVE
|
|
| Hodgkin Lymphoma | no genetic record somatic |
mechanism: Mutation-Driven NF-kappaB Activation (Classic HL)
subtype: Classic HL
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| ectodermal dysplasia and immunodeficiency 2 MONDO:0012806 | AD | Definitive 2025-02-10 |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.