Previous symbols: NMYC. Aliases: bHLHe37, N-myc, MYCNOT.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Esophageal Atresia | susceptibility | |
| Feingold Syndrome | causative germline |
mechanism: Impaired brain and neural development; MYCN haploinsufficiency; Reduced PI3K signaling in limb mesenchyme
subtype: Type 1
animal model: Mouse
scoped to subtype: Type 1
|
| Alveolar Rhabdomyosarcoma |
untyped
Secondary Genetic Event
|
mechanism: YOD1-N-Myc PAX-FOXO1 Feedback Loop
|
| Medulloblastoma, SHH-Activated |
untyped
Amplification
|
|
| Neuroblastoma |
untyped
Oncogene Amplification
|
animal model: Xenopus anteroventral noradrenergic (AVNA) cell differentiation model
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| Feingold syndrome type 1 MONDO:0008115 | AD | Definitive 2025-07-02 |
Feingold Syndrome
causative
|
| megalencephaly-polydactyly syndrome MONDO:0958279 | AD | Moderate 2026-01-07 |
no dismech entry |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.