MYC

MYC (c-Myc) is a nuclear bHLH-leucine zipper transcription factor and major proto-oncogene that regulates cell growth, proliferation, metabolism, and apoptosis. MYC functions primarily through obligate heterodimerization with MAX to bind E-box DNA motifs (CACGTG) at promoters and enhancers, activating transcription of target genes involved in cell cycle progression, ribosome biogenesis, and metabolic programs. MYC can also repress transcription via interaction with MIZ1 (ZBTB17). The protein contains N-terminal transactivation domains with conserved Myc boxes (MBI-MBIV) and a C-terminal bHLH-LZ domain for dimerization and DNA binding. MYC stability is regulated by a phosphodegron at T58/S62 recognized by the E3 ligase FBXW7 for ubiquitin-mediated proteasomal degradation. MYC is deregulated in over 50% of human cancers and regulates approximately 11% of human genes.

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.