Previous symbols: MTTC. Aliases: trnC.
MT-TC (mitochondrially encoded tRNA-Cys (UGU/C)) is named by 1 disorder entry. It is a mitochondrial-DNA-encoded transfer RNA for cysteine.
The pinned ai-gene-review snapshot that the ingest layer reads has no core functions for MT-TC (0 terms). An upstream review of the gene is being added or updated.
One entry types MT-TC as causative: MELAS Syndrome. In MELAS Syndrome the gene sits on the node Non-MT-TL1 mitochondrial tRNA dysfunction, and the entry records the variants as germline. The KB's mechanism annotations for MT-TC name the process mitochondrial translation.
ClinGen classifies MT-TC for 1 disease, mitochondrial disease, which no dismech entry curates. Because the pinned ai-gene-review snapshot has no core functions for the gene, the KB and ai-gene-review currently share 0 GO process terms.
Underlined values are claims re-computed from the knowledge base each time this page is built. The tables below are the source of truth.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| MELAS Syndrome | causative germline |
mechanism: Non-MT-TL1 mitochondrial tRNA dysfunction
subtype: MT-TC
scoped to subtype: MT-TC
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| mitochondrial disease MONDO:0044970 | MT | Limited 2025-07-14 |
no dismech entry |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.