MSX1 - dismech genes

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Tooth Agenesis	causative germline	mechanism: Dental Mesenchyme Transcription Factor Deficiency subtype: MSX1-related scoped to subtype: MSX1-related
Tooth and Nail Syndrome	causative germline
Wolf-Hirschhorn_Syndrome	susceptibility	mechanism: Candidate MSX1-Dependent Odontogenesis Defect
Cleft Lip/Palate	untyped Risk Factor

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
tooth agenesis, selective, 1 MONDO:0007129	AD	Definitive 2024-02-08	Tooth Agenesis causative
tooth and nail syndrome MONDO:0008582	AD	Disputed 2023-10-19	Tooth and Nail Syndrome causative

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.