Aliases: NIK, HSNIK, FTDCR1B, HS.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Classic Hodgkin Lymphoma | somatic driver somatic |
mechanism: Mutation-Driven NF-kappaB Activation
|
| NIK Deficiency | causative germline loss of function |
mechanism: Loss of NIK Kinase Activity
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| NIK deficiency MONDO:0018642 | AR | Moderate 2025-07-17 |
NIK Deficiency
causative
|
Identity from HGNC (snapshot 2026-10-24). Page layers are described in the gene pages documentation.