Aliases: KLA.
KL (klotho) is named by 1 disorder entry. It encodes alpha-Klotho, the co-receptor that FGF23 needs to signal through FGF receptors in the kidney.
The pinned ai-gene-review snapshot that the ingest layer reads has no core functions for KL (0 terms). An upstream review of the gene is being added or updated.
One entry types KL as causative: Hyperphosphatemic Familial Tumoral Calcinosis, recording the variants as germline. There the gene sits on the node Biallelic KL Loss of Function and Renal FGF23 Resistance.
The KB's nodes naming KL carry no GO process annotations (0 terms), and ClinGen classifies the gene for 0 diseases.
Underlined values are claims re-computed from the knowledge base each time this page is built. The tables below are the source of truth.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Hyperphosphatemic Familial Tumoral Calcinosis | causative germline loss of function |
mechanism: Biallelic KL Loss of Function and Renal FGF23 Resistance
subtype: HFTC3
scoped to subtype: HFTC3
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.