KIF5B

kinesin family member 5B

2 disorders 1 causative 1 untyped 10p11.22 gene with protein product

HGNC:6324 Monarch NCBI Gene 3799 ENSG00000170759 UniProt P33176 OMIM 602809

Previous symbols: KNS1. Aliases: KNS, uKHC.

Normal function · from ai-gene-review (P33176, commit 79fe13b38970) · AI-generated, not KB evidence

KIF5B encodes the ubiquitous kinesin-1 heavy chain, an ATP-dependent, plus-end-directed microtubule motor. Its core molecular role is to form kinesin-1 motor complexes that bind microtubules and move vesicles and organelles toward microtubule plus ends. KIF5B is recruited to many cargos through adaptors, including Arl8/SKIP-dependent lysosome positioning, lytic granule polarization in natural killer cells, mitochondrial transport, neuronal cargo transport, centrosome/nuclear positioning, and channel trafficking. Its lysosomal role is kinesin-dependent lysosome localization/positioning through adaptor-mediated cargo recruitment.

ATP-dependent plus-end-directed microtubule motor activity as the kinesin-1 heavy chain, driving transport of vesicles and organelles along microtubules. Cargo specificity is supplied by adaptor proteins and light-chain interactions, so cargo-specific phenotypes should be interpreted as contexts of this core motor function.

molecular function: plus-end-directed microtubule motor activity · directly involved in: vesicle transport along microtubule · locations: cytoskeleton

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
KIF5B-Related Kyphomelic Dysplasia	causative de novogermline dominant negative	mechanism: KIF5B Motor Domain Dysfunction
RET-Rearranged Non-Small Cell Lung Cancer	untyped Fusion Partner

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.