KCNE2

potassium voltage-gated channel subfamily E regulatory subunit 2

2 disorders 1 causative 1 disputed 21q22.11 gene with protein product

HGNC:6242 Monarch NCBI Gene 9992 ENSG00000159197 UniProt Q9Y6J6 OMIM 603796

Aliases: MiRP1, LQT6.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Familial Atrial Fibrillation	causative germline	mechanism: Atrial Ion-Channel or Coupling Variant; Shortened Atrial Action Potential and Refractoriness subtype: KCNE2-related scoped to subtype: KCNE2-related
Familial Long QT Syndrome	disputed	mechanism: QT-Prolonging Drug Unmasking of Reduced Repolarization Reserve subtype: Type 6 scoped to subtype: Type 6

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
long QT syndrome MONDO:0002442	AD	Disputed 2020-12-15	no dismech entry

Mechanism modules · computed from kb/

cardiac_ion_channel_repolarization via Familial Atrial Fibrillation
xenobiotic_cardiac_channel_perturbation via Familial Long QT Syndrome

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.