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IL6ST

interleukin 6 cytokine family signal transducer
2 disorders 1 causative 1 somatic driver 5q11.2 gene with protein product
HGNC:6021MonarchNCBI Gene 3572ENSG00000134352UniProt P40189OMIM 600694

Aliases: GP130, CD130, sGP130, IL-6RB.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
IL6ST-Related Stuve-Wiedemann Syndrome causative germline loss of function
mechanism: Biallelic IL6ST Loss of Function
Unicentric Castleman Disease somatic driver somatic
Mechanism modules · computed from kb/

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.