Previous symbols: IL2R, IDDM10. Aliases: CD25.
ai-gene-review has this gene at status DRAFT; the description is shown only once the review is complete. Read the draft upstream.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Alopecia Areata | susceptibility germline |
mechanism: IFN-gamma–IL-15 JAK-STAT Feedback; Impaired Regulatory T Cell Control
|
| CD25 Deficiency |
causative
germline
CLINGEN: definitive
|
mechanism: IL2RA Coding Frameshift Deletions; IL2RA Coding Frameshift Duplication; IL2RA Coding Substitutions; IL2RA Exon-Level Deletions; IL2RA Splice-Site Substitutions; Impaired High-Affinity IL-2 Capture; Reduced Surface CD25 Availability
|
| Type I Diabetes | susceptibility germline | |
| Diabetes mellitus |
untyped
Susceptibility
|
scoped to subtype: type 1 diabetes mellitus
|
| Multiple Sclerosis |
untyped
Risk Factor
|
mechanism: Th1/Th17-Mediated Neuroinflammation
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| immunodeficiency due to CD25 deficiency MONDO:0011664 | AR | Definitive 2025-02-05 |
CD25 Deficiency
causative
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.