Aliases: IDH-2.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Acute Erythroid Leukemia | cooperating somatic | |
| Chondrosarcoma | somatic driver somatic |
mechanism: IDH1/IDH2 Neomorphic Enzyme Activity
subtype: Conventional; Dedifferentiated; Primary Central
scoped to subtype: Primary Central
|
| Oligoastrocytoma | somatic driver somatic | |
| Acute Myeloid Leukemia, IDH-Mutated |
untyped
Somatic Oncogenic Mutation
|
|
| D-2-Hydroxyglutaric Aciduria | untyped |
subtype: D-2-HGA type II
|
| Diffuse Astrocytoma |
untyped
Somatic Mutation
|
|
| Glioma |
untyped
Somatic Missense Mutation
|
|
| IDH-Mutant and 1p/19q-Codeleted Oligodendroglioma |
untyped
Somatic Mutation
|
|
| IDH-Mutant Astrocytoma |
untyped
Somatic Mutation
|
|
| IDH-Mutant Cholangiocarcinoma |
untyped
Somatic Neomorphic Mutation
|
|
| Peripheral T-Cell Lymphoma |
untyped
Recurrent Somatic Mutation
|
scoped to subtype: TFH Angioimmunoblastic-Type
|
| Sinonasal Undifferentiated Carcinoma |
untyped
Somatic hotspot mutation
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| mitochondrial disease MONDO:0044970 | AD | Definitive 2023-01-30 |
no dismech entry |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.