HRAS

HRas proto-oncogene, GTPase

11 disorders 6 untyped 4 somatic driver 1 no genetic record 11p15.5 gene with protein product

HGNC:5173 Monarch NCBI Gene 3265 ENSG00000174775 UniProt P01112 OMIM 190020

Previous symbols: HRAS1.

Normal function · from ai-gene-review (P01112, commit 79fe13b38970) · AI-generated, not KB evidence

ai-gene-review has this gene at status INITIALIZED; the description is shown only once the review is complete. Read the draft upstream.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Ameloblastoma	somatic driver somatic	mechanism: Somatic RTK-RAS-MAPK Driver Alterations
Embryonal Rhabdomyosarcoma	somatic driver somatic	mechanism: RAS Pathway Activation
Medullary Thyroid Carcinoma	somatic driver somatic	mechanism: RAS Mutation-Driven Proliferation scoped to subtype: Sporadic MTC
Thyroid Follicular Carcinoma	somatic driver somatic	mechanism: RAS and PAX8-PPARG Driver Alterations
Costello Syndrome	untyped Causative	mechanism: Germline HRAS gain-of-function mutation
Cutaneous Squamous Cell Carcinoma	untyped Somatic Mutation
Penile Cancer	untyped Somatic Driver Mutation somatic	mechanism: HPV-Independent Somatic Tumor Suppressor Loss
Thymoma	untyped Recurrent somatic mutation
Transitional Cell Carcinoma	untyped somatic
Vulvar Carcinoma	untyped Somatic Mutation	mechanism: HRAS/RAS-MAPK Signaling Activation
Ethmoid Sinus Adenocarcinoma	no genetic record somatic	mechanism: Heterogeneous Oncogenic Pathway Mutation

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
Costello syndrome MONDO:0009026	AD	Definitive 2018-07-24	Costello Syndrome untyped
Noonan syndrome-like disorder with loose anagen hair MONDO:0011899	AD	Disputed 2018-07-25	Noonan Syndrome-like Disorder with Loose Anagen Hair not named

Mechanism modules · computed from kb/

sustaining_proliferative_signaling via Ameloblastoma, Vulvar Carcinoma

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.