Previous symbols: GOX1. Aliases: GOX.
HAO1 (hydroxyacid oxidase 1) is named by 1 disorder entry.
ai-gene-review gives HAO1's core molecular functions as (S)-2-hydroxy-acid oxidase activity; and FMN binding, acting in glycolate catabolic process in the peroxisomal matrix.
One entry types HAO1 as causative: HAO1-Related Glycolate Oxidase Deficiency, and it records the variants as germline. The gene sits on the node HAO1 Glycolate Oxidase Deficiency. ClinGen classifies HAO1 for 0 diseases, so no validity tier can be copied onto the record.
The KB's HAO1 node and ai-gene-review share glycolate catabolic process by exact identifier. The KB node annotates loss of the gene with glycolate catabolic process; and glyoxylate metabolic process, the second being the downstream consequence of glycolate oxidation rather than a separate activity.
Underlined values are claims re-computed from the knowledge base each time this page is built. The tables below are the source of truth.
ai-gene-review has this gene at status INITIALIZED; the description is shown only once the review is complete. Read the draft upstream.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| HAO1-Related Glycolate Oxidase Deficiency | causative germline |
mechanism: HAO1 Glycolate Oxidase Deficiency
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.