Previous symbols: GLXR, GLYD. Aliases: PH2.
GRHPR (glyoxylate and hydroxypyruvate reductase) is named by 1 disorder entry, Primary Hyperoxaluria Type 2.
ai-gene-review gives GRHPR's core molecular functions as glyoxylate reductase (NADPH) activity; and hydroxypyruvate reductase [NAD(P)H] activity, acting in glyoxylate metabolic process in the cytosol. The KB's GRHPR node shares glyoxylate metabolic process with those core functions. Loss of the two reductase activities explains the paired urinary oxalate and L-glycerate excess that defines the disorder.
Primary Hyperoxaluria Type 2 types GRHPR causative, with the variants recorded as germline, and places the gene on the node GRHPR Glyoxylate Reductase Deficiency.
ClinGen classifies GRHPR for 0 diseases, so no gene-disease validity tier is recorded.
Underlined values are claims re-computed from the knowledge base each time this page is built. The tables below are the source of truth.
ai-gene-review has this gene at status INITIALIZED; the description is shown only once the review is complete. Read the draft upstream.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Primary Hyperoxaluria Type 2 | causative germline |
mechanism: GRHPR Glyoxylate Reductase Deficiency
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.