GPD1 (glycerol-3-phosphate dehydrogenase 1) is named by 1 disorder entry, GPD1 Deficiency.
ai-gene-review gives GPD1's core molecular function as glycerol-3-phosphate dehydrogenase (NAD+) activity, acting in glycerol-3-phosphate metabolic process; glycerol-3-phosphate shuttle; and glycerol-3-phosphate biosynthetic process in the cytosol.
GPD1 Deficiency types GPD1 as causative with a germline variant origin. ClinGen has classified GPD1 for 0 diseases. The gene sits on the node GPD1 Loss of Function, whose decreased activity is the same NAD+-dependent glycerol-3-phosphate dehydrogenase activity the review names as the normal function; downstream nodes carry the glycerol-3-phosphate shuttle and gluconeogenesis processes.
Underlined values are claims re-computed from the knowledge base each time this page is built. The tables below are the source of truth.
ai-gene-review has this gene at status INITIALIZED; the description is shown only once the review is complete. Read the draft upstream.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| GPD1 Deficiency | causative germline |
mechanism: GPD1 Loss of Function
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.