Aliases: CD246, ALK1.
ai-gene-review has this gene at status DRAFT; the description is shown only once the review is complete. Read the draft upstream.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| ALK-Rearranged Non-Small Cell Lung Cancer | somatic driver somatic |
mechanism: ALK fusion oncoprotein formation; ALK kinase-domain mutation-mediated resistance
|
| Anaplastic Large Cell Lymphoma | somatic driver somatic |
mechanism: ALK-Driven STAT3 Activation; Constitutive ALK Fusion Kinase Activity
animal model: Mus musculus
scoped to subtype: Systemic ALK-Positive
|
| Inflammatory Myofibroblastic Tumor |
untyped
Causal somatic gene rearrangement
|
|
| Malignant Peritoneal Mesothelioma |
untyped
Rare Recurrent Rearrangement
|
subtype: ALK-Rearranged
scoped to subtype: ALK-Rearranged
|
| Neuroblastoma |
untyped
Oncogenic Driver Mutations
|
|
| Non-Small Cell Lung Cancer |
untyped
Gene Rearrangements
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| neuroblastoma, susceptibility to, 3 MONDO:0013083 | AD | Definitive 2022-12-30 |
no dismech entry |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.