GALNS

galactosamine (N-acetyl)-6-sulfatase

2 disorders 2 causative 16q24.3 gene with protein product

HGNC:4122 Monarch NCBI Gene 2588 ENSG00000141012 UniProt P34059 OMIM 612222

Aliases: GAS, GALNAC6S, GalN6S.

Normal function · from ai-gene-review (P34059, commit 79fe13b38970) · AI-generated, not KB evidence

ai-gene-review has this gene at status INITIALIZED; the description is shown only once the review is complete. Read the draft upstream.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Morquio syndrome	causative germline	mechanism: Type A GALNS deficiency subtype: Type A scoped to subtype: Type A
Mucopolysaccharidosis	causative germline	mechanism: Lysosomal GAG Accumulation

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
mucopolysaccharidosis type 4A MONDO:0009659	AR	Definitive 2022-06-16	Morquio syndrome causative

Mechanism modules · computed from kb/

mps_gag_storage via Mucopolysaccharidosis

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.