Previous symbols: ALS6. Aliases: TLS, FUS1, hnRNP-P2, HNRNPP2.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Amyotrophic Lateral Sclerosis | causative |
mechanism: RNA-Binding Protein Mislocalization and Stress Granule Dysfunction
subtype: ALS6
treatment: Jacifusen (ION363)
scoped to subtype: ALS6
|
| Essential Tremor | susceptibility | |
| Juvenile Amyotrophic Lateral Sclerosis | causative de novo |
mechanism: FUS Cytoplasmic Mislocalization and Basophilic Inclusion Formation
subtype: ALS6-JALS
scoped to subtype: ALS6-JALS
|
| Liposarcoma | somatic driver somatic |
scoped to subtype: MLPS
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| amyotrophic lateral sclerosis type 6 MONDO:0011951 | AD | Definitive 2021-10-12 |
Amyotrophic Lateral Sclerosis
causative
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.