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ALAS1

5'-aminolevulinate synthase 1
3 disorders 2 no genetic record 1 untyped 3p21.2 gene with protein product
HGNC:396MonarchNCBI Gene 211ENSG00000023330UniProt P13196OMIM 125290

Previous symbols: ALAS3, ALAS. Aliases: ALAS-H.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
Inherited Porphyria untyped
Modifier
mechanism: Hepatic ALAS1 Induction and Acute Precursor Overproduction
Acute Intermittent Porphyria no genetic record
mechanism: Triggered hepatic ALAS1 induction
treatment: Givosiran
Porphyria due to ALA Dehydratase Deficiency no genetic record
mechanism: Hepatic ALAS1 induction and excess ALA production
Mechanism modules · computed from kb/

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.