AHCY across dismech

AHCY (adenosylhomocysteinase) is named by 1 disorder entry.

Normal function

ai-gene-review gives AHCY's core molecular function as adenosylhomocysteinase activity, acting in L-homocysteine biosynthetic process; and L-methionine cycle: the enzyme hydrolyses S-adenosyl-L-homocysteine, the product inhibitor of methyltransferases, to adenosine and homocysteine.

Causative record

The one entry that names AHCY, S-Adenosylhomocysteine Hydrolase Deficiency, types it causative with a germline origin, and records a loss of function impact. ClinGen rates the gene definitive for this disease. The gene sits on the node AHCY Loss of Function, which marks the same adenosylhomocysteinase activity that ai-gene-review gives as the core function as decreased.

Where the layers disagree

The KB's AHCY node carries a molecular-function term but no GO process, so the two layers share 0 process terms by identifier; at the level of molecular function they agree.