DYRK1A

dual specificity tyrosine phosphorylation regulated kinase 1A

3 disorders 3 untyped 21q22.13 gene with protein product

HGNC:3091 Monarch NCBI Gene 1859 ENSG00000157540 UniProt Q13627 OMIM 600855

Previous symbols: DYRK1, DYRK, MNBH.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Autism Spectrum Disorder	untyped Risk Factor
Down_syndrome	untyped Risk Factor
DYRK1A-related intellectual disability syndrome	untyped CAUSAL de novo

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
complex neurodevelopmental disorder MONDO:0100038	AD	Definitive 2020-07-15	no dismech entry

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.