MTFMT across dismech

MTFMT (mitochondrial methionyl-tRNA formyltransferase) is named by 1 disorder entry.

Normal function

MTFMT's normal function is to formylate mitochondrial Met-tRNA(Met) for translation initiation. The ai-gene-review layer currently ingested by dismech lists 0 core-function terms for MTFMT: the pinned ingest predates the upstream review of this gene, which is being completed separately, so this page makes no claim about its GO terms yet.

Disease record

The entry that types MTFMT as causative is Combined Oxidative Phosphorylation Defect Type 15. Its genetic record is causative and the variant origin is recorded as germline. In the entry the gene sits on the node Loss of Mitochondrial Methionyl-tRNA Formyltransferase Activity, which records the loss of formyltransferase activity that generates the mitochondrial initiator fMet-tRNA(Met).

Where the layers meet

The GO processes annotated on the nodes naming MTFMT number 0, and the number of GO process terms shared with ai-gene-review by exact identifier is 0, which follows from the ingest gap above rather than from a disagreement.

ClinGen classifies MTFMT for 1 disease; none matches the entry's own disease term, so the entry carries no ClinGen tier.