Aliases: NPHP7.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Acute Megakaryoblastic Leukemia | somatic driver somatic |
mechanism: CBFA2T3::GLIS2 Induces BMP Signaling and Progenitor Self-Renewal
animal model: mouse
scoped to subtype: CBFA2T3::GLIS2-Positive AMKL
|
| Nephronophthisis | causative |
mechanism: Fibrogenic Transcriptional Derepression
subtype: GLIS2-related
scoped to subtype: GLIS2-related
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| nephronophthisis 7 MONDO:0012680 | AR | Moderate 2026-04-22 |
Nephronophthisis
causative
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.