DMP1 (dentin matrix acidic phosphoprotein 1) is named by 2 disorder entries.
The pinned ai-gene-review ingest carries 0 core-function terms for DMP1; a full upstream review (calcium binding by a secreted bone and dentin matrix phosphoprotein that regulates mineralization) is being added and will appear after the next ingest refresh.
Autosomal Recessive Hypophosphatemic Rickets 1 types DMP1 as causative with germline variants. The gene sits on Biallelic DMP1 Loss of Function, with a loss of function genetic context. ClinGen has classified DMP1 for 0 diseases.
Raine Syndrome names DMP1 on Hypophosphorylation of Secreted Biomineralization Proteins as a FAM20C substrate, without a genetic record for it.
Underlined values are claims re-computed from the knowledge base each time this page is built. The tables below are the source of truth.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Autosomal Recessive Hypophosphatemic Rickets 1 | causative germline loss of function |
mechanism: Biallelic DMP1 Loss of Function
animal model: Dmp1-null mouse
|
| Raine Syndrome | no genetic record |
mechanism: Hypophosphorylation of Secreted Biomineralization Proteins
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.