Browse All / Genes / PARP1

PARP1

poly(ADP-ribose) polymerase 1
6 disorders 6 no genetic record 1q42.12 gene with protein product
HGNC:270MonarchNCBI Gene 142ENSG00000143799UniProt P09874OMIM 173870

Previous symbols: PPOL, ADPRT. Aliases: PARP, ARTD1, Poly-PARP, PARS.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
Aflatoxin-Related Hepatocellular Carcinoma no genetic record
mechanism: PARP1 DNA Repair Suppression
Alzheimer Disease no genetic record
mechanism: PARP1-Mediated Parthanatos
Ewing Sarcoma no genetic record
mechanism: PARP1-Supported Fusion Transcription
Leber Congenital Amaurosis 9 no genetic record
mechanism: PARP Hyperactivation and Nuclear NAD+ Consumption
Ovarian High-Grade Serous Carcinoma no genetic record
mechanism: PARP and Platinum Synthetic Lethality
Spinocerebellar Ataxia, Autosomal Recessive 26 no genetic record
mechanism: PARP1 Trapping and Hyperactivation
Mechanism modules · computed from kb/

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.