Browse All / Genes / CYBB

CYBB

cytochrome b-245 beta chain
5 disorders 2 susceptibility 2 causative 1 untyped Xp21.1-p11.4 gene with protein product
HGNC:2578MonarchNCBI Gene 1536ENSG00000165168UniProt P04839OMIM 300481

Previous symbols: CGD. Aliases: GP91-PHOX, NOX2, GP91PHOX, p91-PHOX.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
Aspergillosis susceptibility
Chronic Granulomatous Disease causative
mechanism: NADPH oxidase (NOX2) complex assembly failure
subtype: X-linked CYBB
scoped to subtype: X-linked CYBB
Invasive Non-Typhoidal Salmonellosis susceptibility
X-linked Mendelian Susceptibility to Mycobacterial Diseases due to CYBB Deficiency causative germline partial loss of function
mechanism: Hypomorphic CYBB Missense Alleles
Systemic Lupus Erythematosus untyped
Associated
mechanism: TLR7/TLR9-Mediated Nucleic Acid Sensing
Mechanism modules · computed from kb/

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.