DNAAF4

dynein axonemal assembly factor 4

2 disorders 1 susceptibility 1 causative 15q21.3 gene with protein product

HGNC:21493 Monarch NCBI Gene 161582 ENSG00000256061 UniProt Q8WXU2 OMIM 608706

Previous symbols: DYX1C1. Aliases: EKN1, FLJ37882, CILD25, pf23.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Dyslexia	susceptibility germline
Primary_Ciliary_Dyskinesia	causative	mechanism: Cytoplasmic Dynein Arm Preassembly Failure subtype: CILD25 scoped to subtype: CILD25

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
primary ciliary dyskinesia 25 MONDO:0014203	AR	Definitive 2024-04-11	Primary_Ciliary_Dyskinesia causative

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.