Aliases: FLJ00026, FLJ00152, ZIR8, FLJ00346.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Chronic Mucocutaneous Candidiasis | causative germline |
mechanism: Loss of the Th17-Inducing Transcriptional Program
|
| Combined Immunodeficiency Due To DOCK8 Deficiency | causativemodifier germlinesomatic |
animal model: Dock8 ENU point-mutant mouse (captain morgan / primurus); Dock8 knockout mouse; Dock8 mutant mouse CD8 T cell compartment
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| combined immunodeficiency due to DOCK8 deficiency MONDO:0009478 | AR | Definitive 2021-04-09 |
Combined Immunodeficiency Due To DOCK8 Deficiency
causative and modifier
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.