ADAM10

ADAM metallopeptidase domain 10

2 disorders 1 risk factor 1 causative 15q21.3 gene with protein product

HGNC:188 Monarch NCBI Gene 102 ENSG00000137845 UniProt O14672 OMIM 602192

Aliases: kuz, MADM, HsT18717, CD156C.

Normal function · from ai-gene-review (O14672, commit e7236877cf14) · AI-generated, not KB evidence

ADAM10 encodes a single-pass type I transmembrane zinc metalloprotease of the ADAM family. The mature enzyme acts mainly at the cell surface, Golgi-derived vesicles, synaptic membranes, adherens junctions, and tetraspanin-enriched membrane domains, where it cleaves extracellular juxtamembrane regions of many membrane proteins. Its core roles are membrane-protein ectodomain shedding and alpha-secretase processing, including non-amyloidogenic cleavage of APP, S2 cleavage of Notch receptors, and processing of adhesion molecules, growth-factor and cytokine precursors, immune receptors, and other signaling substrates. ADAM10 localization, maturation, endocytosis, and substrate selectivity are regulated by tetraspanins, clathrin/AP2-dependent trafficking, and substrate-specific adaptor contexts.

ADAM10 is a zinc-dependent type I membrane metalloendopeptidase that performs ectodomain shedding and alpha-secretase cleavage of transmembrane substrates at the cell surface and regulated membrane compartments.

molecular function: metalloendopeptidase activity · directly involved in: membrane protein ectodomain proteolysis; constitutive protein ectodomain proteolysis; signaling receptor ligand precursor processing; amyloid precursor protein catabolic process; negative regulation of amyloid-beta formation; Notch signaling pathway; epidermal growth factor receptor ligand maturation · locations: plasma membrane; cell surface; Golgi membrane; clathrin-coated vesicle; tetraspanin-enriched microdomain; synaptic membrane

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Alzheimer Disease	risk factor	mechanism: Amyloid Plaque Formation scoped to subtype: Late-Onset Alzheimer's Disease
Reticulate Acropigmentation Of Kitamura	causative germline loss of function	mechanism: ADAM10 Loss of Function

Identity from HGNC (snapshot 2026-10-24). Page layers are described in the gene pages documentation.