RNF43

ring finger protein 43

2 disorders 1 untyped 1 no genetic record 17q22 gene with protein product

HGNC:18505 Monarch NCBI Gene 54894 ENSG00000108375 UniProt Q68DV7 OMIM 612482

Aliases: FLJ20315, RNF124, DKFZp781H0392, URCC.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Pancreatic Mucinous Cystadenoma	untyped PREDISPOSING
Tetraamelia Syndrome 2	no genetic record	mechanism: Unopposed RNF43 and ZNRF3 Activity with Reduced WNT Potentiation

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
sessile serrated polyposis cancer syndrome MONDO:0014919	AD	Definitive 2022-12-30	no dismech entry

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.