Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Brugada syndrome | disputed | |
| Sick Sinus Syndrome 2, Autosomal Dominant | causative |
mechanism: HCN4 Loss-of-Function Variant
|
| Familial Sick Sinus Syndrome |
untyped
Causative
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| sick sinus syndrome 2, autosomal dominant MONDO:0008102 | AD | Definitive 2025-06-24 |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.